Sleep, memory and consciousness
Chairs: Cecilia Forcato (Argentina) and Felipe Beijamini (Brazil)
Summary: The study of the role of sleep in memory formation, its interaction with stress and the processing of information during sleep is a frontier topic in neuroscience. In this Symposium we will discuss the active role of sleep in memory consolidation as well as the interaction between sleep and stress and the processing of information in this state of reduced consciousness.
- Presentation 1: Memory formation during sleep – the role of spindles - Speaker: Jan Born (Germany)
- Presentation 2: Sleep-dependent plasticity and memory change: Strengthening, forgetting, and restructuring - Speaker: Sidarta Ribeiro (Brazil)
- Presentation 3: Stress, Sleep, and Memory Consolidation: Independent and Interactive Effects - Speaker: Jessica Payne (USA)
- Presentation 4: Fragmentation and resilience of Cognitive processes as we fall asleep - Speaker: Tristán Bekinschtein (England/Argentina)
The consequences of memory retrieval: reconsolidation, extinction or nothing at all
Chair: Pedro Bekinschtein (Argentina)
Summary: During the past 15 years, the memory research field has increased interest in examining the consequences of retrieving a memory. The finding that inhibition of protein synthesis after retrieval was able to impair the original memory led to the construction of the destabilization-reconsolidation theory. There is accumulating evidence that, under certain conditions, retrieval can result in memory reconsolidation. However, for an associative memory, retrieval can also engage extinction of the original association. Recently, a handful of studies have started to identify the boundaries between reconsolidation and extinction with quite surprising results. In addition, there is also new evidence that indicates that memory expression might not be a required condition for reconsolidation to occur. In this symposium, we will discuss these subjects with pioneering scientists that have actively tried to identified the system, cellular and molecular establishment of the boundaries between reconsolidation and extinction and the relationship between retrieval, reconsolidation and extinction.
- Presentation 1: On the mutable nature of active memories - Speaker: Martín Cammarota (Brazil)
- Presentation 2: Brain dynamics in fear memory: expression, labilization and reconsolidation - Speaker: Verónica de la Fuente (Argentina)
- Presentation 3: Retrieval-induced plasticity: reconsolidation, extinction and no man's land - Speaker: Emiliano Merlo (UK)
- Presentation 4: Cortical serotonin controls retrieval and reconsolidation of recognition memoryJ10 - Speaker: Noelia Weisstaub (Argentina)
Auditory Processing: From the cochlea to the cortex and back
Chairs: Eleonora Katz (Argentina) and María Eugenia Gomez Casati (Argentina)
Summary: This symposium will provide an updated view of some key points in auditory processing. Namely, sound encoding at the cochlear hair cell-afferent neuron synapse; the synaptic organization of midbrain nuclei where auditory signals are further processed before reaching the cortex and, back to the cochlea with cortico-olivocochlear fibers that modulate the gain of the system by an inhibitory synapse.
- Presentation 1: Synaptic mechanisms of sound encoding in the mammalian inner ear - Speaker: Juan Goutman (Argentina)
- Presentation 2: Reorganization of local synaptic connections in the auditory midbrain during development and disease - Speaker: Karl Kandler (USA)
- Presentation 3: Modulation of cochlear sensitivity during selective attention: a possible function of cortico-olivocochlear pathways - Speaker: Paul Delano (Chile)
- Presentation 4: Cholinergic Inhibition of Cochlear Hair Cells - Speaker: Paul Fuchs (USA)
Neuroesteroids, cardioesteroids and oxidative cell signalling as target in neuroinflammation and possible role in neurodegenerative disease
Chair: Fernando Benetti (Brazil)
Summary: The increased longevity of the world's population has been accompanied by an exponential growth in the number of people with neurodegenerative diseases. Several studies have shown multiple actions of progesterone, estrogen, neuroactive steroids, cardiosteroids as well cell oxidation, controll signaling pathways involved in neuronal death, thus are potential candidates for prevent these brain disease.
- Presentation 1: Neuroinflamation and mnemonic deficits - Speaker: Weber Claudio Francisco Nunes da Silva (Brazil)
- Presentation 2: Neuroinflammation and Brain plasticity induced by cardiosteroids - Speaker: Cristoforo Scavone (Brazil)
- Presentation 3: Role of estrogen receptors in the regulation of neuroinflammation - Speaker: Luis Miguel Garcia Segura (Spain)
- Presentation 4: Progestins as anti-inflammatory factors in neurological disorders - Speaker: Alejandro Federico de Nicola (Argentina)
Neurophysiology of temporal processing in the brain
Chairs: Patricia Agostino (Argentina) and Hugo Merchant (Mexico)
Summary: A fundamental component of cognition is the perception of the passage of time. In particular, temporal processing within the 10-2 to 102 seconds is crucial for many complex behaviors, such as speech comprehension, motor control, and decision-making. The goal for this symposium is to present studies of temporal processing in humans and animals using a diversity of experimental and analytical tools.
- Presentation 1: Neural underpinnings of time perception in the primate: prefrontal and premotor single unit activity during a categorization task of temporal magnitudes - Speaker: Dr. Hugo Merchant (Mexico)
- Presentation 2: Basal ganglia contributions to a time-based decision - Speaker: Dr. Joseph J. Paton (Portugal)
- Presentation 3: Temporal rhythm perception in monkeys and humans - Speaker: Dr. Víctor de Lafuente (Mexico)
- Presentation 4: Temporal processing in the milliseconds and seconds range - Speaker: Dr. Rodrigo Laje (Argentina)
New insights into synaptic plasticity
Chair: Antonio Rodriguez-Moreno (Spain)
Summary: Synaptic plasticity is one of the main properties of the brain. Understanding the mechanisms and functions of plasticity in development, learning and memory, as well as recovery after brain injury is an important topic with wide appeal, and this controversial topic will promote an interesting debate and contribute to clarity in a sometimes confusing field.
- Presentation 1: Spike timing-dependent plasticity in the cortex and the hippocampus - Speaker: Antonio Rodriguez Moreno (Spain)
- Presentation 2: Astrocyte-Neuron signaling on synaptic plasticity - Speaker: Gertrudis Perea Parrilla (Spain)
- Presentation 3: Activity-dependent synaptic plasticity of GABAergic synapses - Speaker: Marco A Fuenzalida Núñez (Chile)
- Presentation 4: Endocrine factors-mediated regulation of synaptic plasticity - Speaker: Eduardo D. martín Montiel (Spain)
Macromolecular signaling complexes in neurons
Chairs: Mark Shapiro (USA) and Francisco Barrantes (Argentina)
Summary: Signaling cascades that regulate neuronal activity use limited number of second messengers, therefore, in order for intracellular signaling to function with high fidelity, a precise spatiotemporal localization of intracellular signals must exist. Leading scientists from three continents will discuss current hot topics and technical advances in the field of neuronal localised intracellular signaling.
- Presentation 1: Assembly of diverse ion channels into multi-channel complexes, mediated by A-kinase Anchoring Protein 79/150, observed by STORM super-resolution nanoscopy - Speaker: Mark S Shapiro (USA)
- Presentation 2: Allosterism and structure in TRP channels - Speaker: Ramon Latorre (Chile)
- Presentation 3: Nanoscale organization and protein-lipid interactions of the nicotinic acetylcholine receptor - Speaker: Francisco J. Barrantes (Argentina)
- Presentation 4: Localised GPCR signaling at plasma membrane-ER junctions - Speaker: Nikita Gamper (UK)
Neuroimmunoendocrinology of the circadian system
Chair: Diego Golombek (Argentina)
Summary: Circadian rhythms in immune, endocrine and metabolic parameters, are controlled by a central suprachiasmatic clock. Desynchronization schedules severely affect humoral and autonomic rhythms, resulting in diverse pathological dysfunctions. Immune and endocrine signals feedback and regulate the clock. This symposium will present neuroimmunoendocrine interactions with the circadian timing system.
- Presentation 1: Interaction between the brain and the immune system: the circadian autonomic reflex - Speaker: Ruud Buijs (Mexico)
- Presentation 2: The immune-pineal axis - melatonin synthesized by microglia and macrophages play a role in neuro and peripheral protection - Speaker: Regina Markus (Brazil)
- Presentation 3: Internal desynchronization of circadian rhythms and the immune system - Speaker: Horacio de la Iglesia (USA)
- Presentation 4: Circadian desynchronization in a murine model of chronic JET-LAG: effects on metabolism and in experimental tumorigenesis - Speaker: Juan José Chiesa (Argentina)
Novel insights into hypothalamic mechanisms controlling body homeostasis
Chair: Mario Perello (Argentina)
Summary: The hypothalamus is a functionally and structurally complex brain structure that constantly integrates a variety of peripheral signals and generates combined physiological responses essential for the body homeostasis regulation. In this symposium, we will present an update of some novel aspects of these very sophisticated and recently elucidated hypothalamic mechanisms.
- Presentation 1: Neuronal circuits by which ghrelin regulates stress and eating bahaviors - Speaker: Dr. Mario Perello (Argentina)
- Presentation 2: Leptin signaling in hypothalamus: metabolic adaptations to pregnancy - Speaker: Dr. JOSE DONATO JUNIOR (Brazil)
- Presentation 3: Non-conventional modalities of neurotransmission in the hypothalamus: where the tortoise and the hare meet - Speaker: Dr. JAVIER E. STERN (USA)
- Presentation 4: A novel role for hypothalamic glia in the control of systemic metabolism - Speaker: MATTHIAS TSCHÖP (Germany)
New concepts in oligodendrocyte function in neurological diseases
Chair: Babette Fuss (USA) and Cecilia Hedin-Pereira (Brazil)
Summary: This symposium will present novel findings related to the role of oligodendrocytes, the myelinating cells of the CNS, as potential targets for the treatment of a variety of neurological diseases. These include the demyelinating disease Multiple Sclerosis and a number of behavioral and neuropsychiatric disorders more recently recognized to involve oligodendrocyte/myelin dysfunction and/or loss.
- Presentation 1: The autotaxin-LPA axis as a regulator of myelination and remyelination - Speaker: Babette Fuss (USA)
- Presentation 2: Myelin and oligodendrogenesis in a mouse depression model - Speaker: Cecilia Hedin-Pereira (Brazil)
- Presentation 3: Myelin alteration and behavioural disorders - Speaker: Juana M.Pasquini (Argentina)
- Presentation 4: The effects of experience on brain myelination: mechanisms and implications - Speaker: Gabriel Corfas (USA)
NeuroFrames symposium - Freud revisited: computational psychiatry
Chair: Jacobo Sitt (France)
Summary: Since the onset of Psychiatry, clinical interviews are the base of mental disease diagnosis. Computational Psychiatry aims at objectively quantifying and modeling patient’s signs and symptoms. The ultimate objective of this new discipline is to develop clinical evaluation tools complementary to the expert’s opinion. Here, we will present this new discipline and successful implementations.
- Presentation 1: The new sub-conscious, Sigmund Freud meets XXI century neuroscience - Speaker: Lionel Naccache (France)
- Presentation 2: A quantitative reassessment of dreams as the royal road to the unconscious - Speaker: Sidarta Ribeiro (Brazil)
- Presentation 3: Electrophysiological correlates of the first person report - Speaker: Jacobo Sitt (France)
- Presentation 4: Automated characterization of mental states: a natural language processing approach - Speaker: Diego Fernandez Slezak (Argentina)
Patient-derived induced pluripotent stem-like cells as models for neurodegenerative diseses
Chair: Lisandro J. Falomir Lockhart (Argentina)
Summary: Discovery of cellular induced pluripotency and reprogramming extended the horizons of medicine for the near future. Significant effort has been made to understand and control these processes, and now we can manipulate readily accessible cells from patients to resemble those from inaccessible tissues, such as the brain. Reproducing complex diseases in a dish allow us to study their molecular basis.
- Presentation 1: Use of human induced pluripotent stem cells for modelling the neuronopathic form of gaucher's disease: insights into disease mechanism and development of a platform for pharmacological compound testing - Speaker: Gustavo TISCORNIA, PhD (Portugal)
- Presentation 2: Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration. - Speaker: Gerson CHADI, MD PhD (Brazil)
- Presentation 3: Unraveling the role of LRRK2 mutations in Parkinson´s disease - Speaker: Birgitt SCHÜLE, MD, PhD (USA)
- Presentation 4: Metabolic and differentiation impairment in Parkinson’s disease patient-derived iPSCs with a triplication event including the SNCA Locus. - Speaker: Lisandro J. FALOMIR LOCKHART (Argentina)