Sleep, memory and consciousness

Chairs: Cecilia Forcato (Argentina) and Felipe Beijamini (Brazil)
Summary: The study of the role of sleep in memory formation, its interaction with stress and the processing of information during sleep is a frontier topic in neuroscience. In this Symposium we will discuss the active role of sleep in memory consolidation as well as the interaction between sleep and stress and the processing of information in this state of reduced consciousness.
- Presentation 1: Memory formation during sleep – the role of spindles  -  Speaker: Jan Born (Germany)
- Presentation 2: Sleep-dependent plasticity and memory change: Strengthening, forgetting, and restructuring -  Speaker: Sidarta Ribeiro (Brazil)
- Presentation 3: Stress, Sleep, and Memory Consolidation: Independent and Interactive Effects  -  Speaker: Jessica Payne (USA)
- Presentation 4: Fragmentation and resilience of Cognitive processes as we fall asleep  -  Speaker: Tristán Bekinschtein (England/Argentina)

The consequences of memory retrieval: reconsolidation, extinction or nothing at all

Chair: Pedro Bekinschtein (Argentina)
Summary: During the past 15 years, the memory research field has increased interest in examining the consequences of retrieving a memory. The finding that inhibition of protein synthesis after retrieval was able to impair the original memory led to the construction of the destabilization-reconsolidation theory. There is accumulating evidence that, under certain conditions, retrieval can result in memory reconsolidation. However, for an associative memory, retrieval can also engage extinction of the original association. Recently, a handful of studies have started to identify the boundaries between reconsolidation and extinction with quite surprising results. In addition, there is also new evidence that indicates that memory expression might not be a required condition for reconsolidation to occur. In this symposium, we will discuss these subjects with pioneering scientists that have actively tried to identified the system, cellular and molecular establishment of the boundaries between reconsolidation and extinction and the relationship between retrieval, reconsolidation and extinction.
- Presentation 1: On the mutable nature of active memories  -  Speaker: Martín Cammarota (Brazil)
- Presentation 2: Brain dynamics in fear memory: expression, labilization and reconsolidation  -  Speaker: Verónica de la Fuente (Argentina)
- Presentation 3: Retrieval-induced plasticity: reconsolidation, extinction and no man's land  -  Speaker: Emiliano Merlo (UK)
- Presentation 4: Cortical serotonin controls retrieval and reconsolidation of recognition memoryJ10 - Speaker: Noelia Weisstaub (Argentina)

Auditory Processing: From the cochlea to the cortex and back

Chairs: Eleonora Katz (Argentina) and María Eugenia Gomez Casati (Argentina)
Summary: This symposium will provide an updated view of some key points in auditory processing.  Namely, sound encoding at the cochlear hair cell-afferent neuron synapse; the synaptic organization of midbrain nuclei where auditory signals are further processed before reaching the cortex and, back to the cochlea with cortico-olivocochlear fibers that modulate the gain of the system by an inhibitory synapse.
- Presentation 1: Synaptic mechanisms of sound encoding in the mammalian inner ear  -  Speaker: Juan Goutman (Argentina)
- Presentation 2: Reorganization of local synaptic connections in the auditory midbrain during development and disease  -  Speaker: Karl Kandler (USA)
- Presentation 3: Modulation of cochlear sensitivity during selective attention: a possible function of cortico-olivocochlear pathways  -  Speaker: Paul Delano (Chile)
- Presentation 4: Cholinergic Inhibition of Cochlear Hair Cells  -  Speaker: Paul Fuchs (USA)

Neuroesteroids, cardioesteroids and oxidative cell signalling as target in neuroinflammation and possible role in neurodegenerative disease

Chair: Fernando Benetti (Brazil)
Summary: The increased longevity of the world's population has been accompanied by an exponential growth in the number of people with neurodegenerative diseases. Several studies have shown multiple actions of progesterone, estrogen, neuroactive steroids, cardiosteroids as well cell oxidation, controll signaling pathways involved in neuronal death, thus are potential candidates for prevent these brain disease.
- Presentation 1: Neuroinflamation and mnemonic deficits  -  Speaker: Weber Claudio Francisco Nunes da Silva (Brazil)
- Presentation 2: Neuroinflammation and Brain plasticity induced by cardiosteroids  -  Speaker: Cristoforo Scavone (Brazil)
- Presentation 3: Role of estrogen receptors in the regulation of neuroinflammation  -  Speaker: Luis Miguel Garcia Segura (Spain)
- Presentation 4: Progestins as anti-inflammatory factors in neurological disorders  -  Speaker: Alejandro Federico de Nicola (Argentina)

Neurophysiology of temporal processing in the brain

Chairs: Patricia Agostino (Argentina) and Hugo Merchant (Mexico)
Summary: A fundamental component of cognition is the perception of the passage of time. In particular, temporal processing within the 10-2 to 102 seconds is crucial for many complex behaviors, such as speech comprehension, motor control, and decision-making. The goal for this symposium is to present studies of temporal processing in humans and animals using a diversity of experimental and analytical tools.
- Presentation 1: Neural underpinnings of time perception in the primate: prefrontal and premotor single unit activity during a categorization task of temporal magnitudes - Speaker: Dr. Hugo Merchant (Mexico)
- Presentation 2: Basal ganglia contributions to a time-based decision - Speaker: Dr. Joseph J. Paton (Portugal)
- Presentation 3: Temporal rhythm perception in monkeys and humans - Speaker: Dr. Víctor de Lafuente (Mexico)
- Presentation 4: Temporal processing in the milliseconds and seconds range - Speaker: Dr. Rodrigo Laje (Argentina)

New insights into synaptic plasticity

Chair: Antonio Rodriguez-Moreno (Spain)
Summary: Synaptic plasticity is one of the main properties of the brain. Understanding the mechanisms and functions of plasticity in development, learning and memory, as well as recovery after brain injury is an important topic with wide appeal, and this controversial topic will promote an interesting debate and contribute to clarity in a sometimes confusing field.
- Presentation 1: Spike timing-dependent plasticity in the cortex and the hippocampus - Speaker: Antonio Rodriguez Moreno (Spain)
- Presentation 2: Astrocyte-Neuron signaling on synaptic plasticity - Speaker: Gertrudis Perea Parrilla (Spain)
- Presentation 3: Activity-dependent synaptic plasticity of GABAergic synapses - Speaker: Marco A Fuenzalida Núñez (Chile)
- Presentation 4: Endocrine factors-mediated regulation of synaptic plasticity - Speaker: Eduardo D. martín Montiel (Spain)

Macromolecular signaling complexes in neurons

Chairs: Mark Shapiro (USA) and Francisco Barrantes (Argentina)
Summary: Signaling cascades that regulate neuronal activity use limited number of second messengers, therefore, in order for intracellular signaling to function with high fidelity, a precise spatiotemporal localization of intracellular signals must exist. Leading scientists from three continents will discuss current hot topics and technical advances in the field of neuronal localised intracellular signaling.
- Presentation 1: Assembly of diverse ion channels into multi-channel complexes, mediated by A-kinase Anchoring Protein 79/150, observed by STORM super-resolution nanoscopy - Speaker: Mark S Shapiro (USA)
- Presentation 2: Allosterism and structure in TRP channels - Speaker: Ramon Latorre (Chile)
- Presentation 3: Nanoscale organization and protein-lipid interactions of the nicotinic acetylcholine receptor - Speaker: Francisco J. Barrantes (Argentina)
- Presentation 4: Localised GPCR signaling at plasma membrane-ER junctions - Speaker: Nikita Gamper (UK)

Neuroimmunoendocrinology of the circadian system

Chair: Diego Golombek (Argentina)
Summary: Circadian rhythms in immune, endocrine and metabolic parameters, are controlled by a central suprachiasmatic clock. Desynchronization schedules severely affect humoral and autonomic rhythms, resulting in diverse pathological dysfunctions. Immune and endocrine signals feedback and regulate the clock. This symposium will present neuroimmunoendocrine interactions with the circadian timing system.
- Presentation 1: Interaction between the brain and the immune system: the circadian autonomic reflex - Speaker: Ruud Buijs (Mexico)
- Presentation 2: The immune-pineal axis - melatonin synthesized by microglia and macrophages play a role in neuro and peripheral protection - Speaker: Regina Markus (Brazil)
- Presentation 3: Internal desynchronization of circadian rhythms and the immune system - Speaker: Horacio de la Iglesia (USA)
- Presentation 4: Circadian desynchronization in a murine model of chronic JET-LAG: effects on metabolism and in experimental tumorigenesis - Speaker: Juan José Chiesa (Argentina)

Novel insights into hypothalamic mechanisms controlling body homeostasis

Chair: Mario Perello (Argentina)
Summary: The hypothalamus is a functionally and structurally complex brain structure that constantly integrates a variety of peripheral signals and generates combined physiological responses essential for the body homeostasis regulation. In this symposium, we will present an update of some novel aspects of these very sophisticated and recently elucidated hypothalamic mechanisms.
- Presentation 1: Neuronal circuits by which ghrelin regulates stress and eating bahaviors - Speaker: Dr. Mario Perello (Argentina)
- Presentation 2: Leptin signaling in hypothalamus: metabolic adaptations to pregnancy - Speaker: Dr. JOSE DONATO JUNIOR (Brazil)
- Presentation 3: Non-conventional modalities of neurotransmission in the hypothalamus: where the tortoise and the hare meet - Speaker: Dr. JAVIER E. STERN (USA)
- Presentation 4: A novel role for hypothalamic glia in the control of systemic metabolism - Speaker: MATTHIAS TSCHÖP (Germany)

New concepts in oligodendrocyte function in neurological diseases

Chair: Babette Fuss (USA) and Cecilia Hedin-Pereira (Brazil)
Summary: This symposium will present novel findings related to the role of oligodendrocytes, the myelinating cells of the CNS, as potential targets for the treatment of a variety of neurological diseases. These include the demyelinating disease Multiple Sclerosis and a number of behavioral and neuropsychiatric disorders more recently recognized to involve oligodendrocyte/myelin dysfunction and/or loss.
- Presentation 1: The autotaxin-LPA axis as a regulator of myelination and remyelination - Speaker: Babette Fuss (USA)
- Presentation 2: Myelin and oligodendrogenesis in a mouse depression model - Speaker: Cecilia Hedin-Pereira (Brazil)
- Presentation 3: Myelin alteration and behavioural disorders - Speaker: Juana M.Pasquini (Argentina)
- Presentation 4: The effects of experience on brain myelination: mechanisms and implications - Speaker: Gabriel Corfas (USA)

NeuroFrames symposium - Freud revisited: computational psychiatry

Chair: Jacobo Sitt (France)
Summary: Since the onset of Psychiatry, clinical interviews are the base of mental disease diagnosis. Computational Psychiatry aims at objectively quantifying and modeling patient’s signs and symptoms. The ultimate objective of this new discipline is to develop clinical evaluation tools complementary to the expert’s opinion. Here, we will present this new discipline and successful implementations.
- Presentation 1: The new sub-conscious, Sigmund Freud meets XXI century neuroscience - Speaker: Lionel Naccache (France)
- Presentation 2: A quantitative reassessment of dreams as the royal road to the unconscious - Speaker: Sidarta Ribeiro (Brazil)
- Presentation 3: Electrophysiological correlates of the first person report - Speaker: Jacobo Sitt (France)
- Presentation 4: Automated characterization of mental states: a natural language processing approach - Speaker: Diego Fernandez Slezak (Argentina)


Patient-derived induced pluripotent stem-like cells as models for neurodegenerative diseses

Chair: Lisandro J. Falomir Lockhart (Argentina)
Summary: Discovery of cellular induced pluripotency and reprogramming extended the horizons of medicine for the near future. Significant effort has been made to understand and control these processes, and now we can manipulate readily accessible cells from patients to resemble those from inaccessible tissues, such as the brain. Reproducing complex diseases in a dish allow us to study their molecular basis.
- Presentation 1: Use of human induced pluripotent stem cells for modelling the neuronopathic form of gaucher's disease: insights into disease mechanism and development of a platform for pharmacological compound testing - Speaker: Gustavo TISCORNIA, PhD (Portugal)
- Presentation 2: Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration. - Speaker: Gerson CHADI, MD PhD (Brazil)
- Presentation 3: Unraveling the role of LRRK2 mutations in Parkinson´s disease - Speaker: Birgitt SCHÜLE, MD, PhD (USA)
- Presentation 4: Metabolic and differentiation impairment in Parkinson’s disease patient-derived iPSCs with a triplication event including the SNCA Locus. - Speaker: Lisandro J. FALOMIR LOCKHART (Argentina)

The interplay of neuronal activity, synaptogenesis and plasticity

Chair: Damian Refojo (Argentina)
Summary: Environmental inputs shape the wiring of the brain influencing timing, dynamics and efficiency of the synaptic connectivity. In this context we proposed to deeply but broadly discuss how different aspects of neuronal activity controls synaptogenesis, cell fate, plasticity and intracellular signaling processes and inversely how those processes influence how neurons perceive and process activity.
- Presentation 1: Firing rate homeostasis in visual cortical circuits - Speaker: Gina Turrigiano (USA)
- Presentation 2: Activity-dependent plasticity of the axon initial segment and its synapses - Speaker: Juan Burrone (UK)
- Presentation 3: Interplay between calcium-dependent activity and morphogenetic proteins during nervous system development - Speaker: Laura Borodinsky (USA)
- Presentation 4: Neddylation, a new postranslational modification in the synapse - Speaker: Damian Refojo (Argentina)

Regulation and function of gap junctions and hemichannels in the nervous system

Chairs: Juan Carlos Saez (Chile) and Alberto Pereda (USA)
Summary: Gap junctions are clusters of intercellular channels widely expressed in the nervous system that are formed by the apposition of two hemichannels. Hemichannels can also function independently providing conduits for the release or uptake of molecules. We will discuss recent progress regarding cellular and molecular mechanisms underlying their function under normal and pathological conditions.
- Presentation 1: Hypothalamic connexins and hypothalamic glucosensing - Speaker: Maria de los Angeles Garcia (Chile)
- Presentation 2: Functional interaction between voltage gated channels and gap junctions in the mammalian brain - Speaker: Sebastian Curti (Uruguay)
- Presentation 3: Pannexin-1 regulates catecholamine release from neuroendocrine chromaffin cells via a functional coupling with the α7 nicotinic receptor - Speaker: Ana Maria Cardenas (Chile)
- Presentation 4: Connexinopathies: a functional and structural glimpse - Speaker: Agustin Martinez (Chile)

The glial cell-neuron regulatory crosstalk

Chair: Rommy von Bernhardi (Chile)
Summary: Glia serve pivotal functions both in the healthy and the diseased CNS. Although their individual properties are known, much less is known about how glia regulate neuronal function. We will address this fundamental problem by discussing in vitro and in vivo evidence on key mechanisms including CNS injury, regulation of synaptic function, and glia-mediated neuro-protection and - degeneration.
- Presentation 1: The diversity of glial responses in acute CNS injuries – lessons from transgenic mice - Speaker: Prof. Dr. Frank Kirchhoff (Germany)
- Presentation 2: Mesenchymal stem cell therapy following intraspinal axotomy: effects on glial cells and neuronal survival - Speaker: Prof. Dr. Alexandre Rodrigues de Oliveira (Brazil)
- Presentation 3: Regulation of microglia-mediated neurodegeneration - Speaker: Rommy von Bernhardi (Chile)
- Presentation 4: Microglia and the antipsychotic effects of cannabidiol - Speaker: Prof. Dr. Francisco Silveira Guimarães (Brazil)

Dopamine neurons: connectivity, functional connectivity and susceptibility

Chair: J. Paul Bolam (UK)
Summary: We will address new findings about how inputs to dopamine neurons control their firing (Henny), how brainstem cholinergic inputs modulate their responsiveness (Mena-Segovia) and how their output may underlie their susceptibility in PD (Bolam). Finally, we will discuss how the symptoms of PD may not entirely be due to the loss of DA (Schiaveto de Souza)
- Presentation 1: Characterization and role of the excitozone/axon initial segment of substantia nigra dopaminergic neurons - Speaker: Pablo Henny (Chile)
- Presentation 2: Cholinergic signaling in the VTA: functional implications for dopamine subcircuits - Speaker: Juan Mena-Segovia (USA)
- Presentation 3: The output of dopamine neurons: clues to susceptibility in PD - Speaker: J. Paul Bolam (UK)
- Presentation 4: Influence of non-dopaminergic transmission on symptoms in rodent models of PD - Speaker: Albert Schiaveto de Souza (Brazil)


Chair: Antonio C. Roque (Brazil)
Summary: Recent advances in the Neurosciences make evident the need for the development of new mathematical objects and theories to accommodate the vast amount of data and build bridges across the different scales, from the cellular to the systems level. This symposium will put together top researchers working on present day frontiers in the interface between mathematics and neuroscience, and will provide an overview on recent developments in the field.
- Presentation 1: Statistics of brain networks - Speaker: Daniel Fraiman (Argentina)
- Presentation 2: Retrieving a context tree from EEG data - Speaker: Cláudia D. Vargas (Brazil)
- Presentation 3: Consciousness measured: Heuristic metrics to track large-scale brain states - Speaker: Ariel Haimovici (Argentina)
- Presentation 4: Applications of a stochastic spiking neuron model to neural network modeling - Speaker: Antonio C. Roque (Brazil)

Parkinson's disease: from neuronal death to therapeutics

Chairs: Juan Ferrario and Gustavo Murer (Argentina)
Summary: The etiology of Parkinson’s Disease (PD) is unknown and its treatment is still unresolved due L-DOPA side effects. We cover promising and challenging areas in basic research of PD:  neuronal death, immunotherapy, genetic approaches (MV & CH) and pathophysiology of Dyskinesias (RM). Authors are top ranked and produce resonant contributions. We are willing to favor poster discussion and networking.
- Presentation 1: The basal ganglia and Parkinson's disease - Speaker: Gustavo Murer (Argentina)
- Presentation 2: Endoplastic Reticulum proteostasis alterations in brain diseases - Speaker: Claudio Hetz (Chile)
- Presentation 3: Aplha-synuclein spreading in Parkinson's disease - Speaker: Miquel Vila (Spain)
- Presentation 4: Role of dopaminergic receptors in Levodopa induced dyskinesias - Speaker: Rosario Moratalla (Spain)

Cellular and molecular mechanisms of neuronal plasticity

Chairs: Francesco Rossi and Nathalia Vitureira (Uruguay)
Summary: The Symposium will focus on different aspect of neuronal plasticity: from learning and memory to pathology, from neuronal to astrocyte signaling, and from molecular mechanisms to behavior. This symposium brings together Latin-American and international researchers in this field to share their outstanding recent findings with the neuroscience community.
- Presentation 1: Mechanism in synaptic plasticity in health and disease. - Speaker: Mauro Costa-Mattioli (USA)
- Presentation 2: Astrocyte-derived exosomes in neural plasticity. - Speaker: Ursula Wyneken (Chile)
- Presentation 3: Pannexin 1, a new actor in synaptic physiology. - Speaker: Alvaro Ardiles (Chile)
- Presentation 4: Synaptic metaplasticity in the visual cortex: interaction between visual experience and reactive oxygen species. - Speaker: Roberto De Pasquale (Brazil)

ISN Symposium on Neural Control of Appetite - From genes to circuits and behavior

Chairs: Ivan E. de Araujo (USA) and Viviana F. Bumaschny (Argentina)
Summary: The inability to maintain a stable body weight in the presence of abundant calories is a hallmark of mammalian species. This symposium will review novel insights into different neural circuits underlying appetite that are influenced by food reward and body energy stores. Emphasis will be placed on how cutting-edge neurobiological tools may assist in understanding the physiopathology of obesity.
- Presentation 1: Circuit logic of food reward - Speaker: Luis A. Tellez (USA)
- Presentation 2: Proopiomelanocortin control of food intake - Speaker: Viviana F. Bumaschny (Argentina)
- Presentation 3: Hypothalamic dysfunction in obesity - Speaker: Licio A. Velloso (Brazil)
- Presentation 4: Orexin/hypocretin neurons and energy balance - Speaker: Denis Burdakov (UK)

Behavioral, neurochemical and molecular approaches to study fear anxiety and posttraumatic stress disorder

Chair: Andrea Mora Gallegos (Costa Rica)
Summary: Anxiety, fear and post-traumatic stress are among the major disorders of modern humanity. There are different approaches to assess them.
Behavioral, neurochemical and molecular  analysis bring information about the  related neuronal mechanisms and the brain  areas involved in. This Symposium will address different  analysis levels to better under stand the above mentioned disorders and how they  could influence processes like learning and behavior.
- Presentation 1: Understanding the role of prelimbic neurons in anxiety regulation - Speaker: Jose Rodríguez-Romaguera (Puerto Rico)
- Presentation 2: Housing effects and the reversion of those conditions on fear conditioning and anxiety - Speaker: Andrea Mora-Gallegos (Costa Rica)
- Presentation 3: Fear and conditioned safety in adult rats: the role of cathecolaminergic neurotransmitters and brain derived neurotropic factor (BDNF) - Speaker: Carol Vásquez Saldaña (Panama)
- Presentation 4: FKBP5 in the medial prefrontal cortex modulates fear conditioning and extinction - Speaker: James T. Porter (Puerto Rico)

Integrative sensory motor function: from motor commands to cognition

Chair: Pedro Maldonado (Chile)
Summary: Motor and sensory processes of the brain are not functional separated. Sensory processing is required for proper motor function, and motor commands are also an intrinsic component of sensory processes. In this symposium, we discuss several mechanism that shed light on how the motor and sensory systems interact in complex behaviors that range from an escape response to cognitive abilities...
- Presentation 1: Increase in sensory sampling triggered by an identified motor command in a lower vertebrate - Speaker: Michel Borde (Uruguay)
- Presentation 2: Neuronal mechanisms of active sensing in vision and touch - Speaker: Pedro Maldonado (Chile)
- Presentation 3: Gamma or no gamma: the role of neuronal oscillations in visual processing - Speaker: Sergio Neuenschwander (Brazil)
- Presentation 4: Early detection of intentional harm in the human amygdala - Speaker: Agustin Ibañez (Argentina)

IBRO Alumni Symposium: Basic and translational research in Neurodegenerative disease: from molecules to animal models

Chair: Valeria Della Maggiore (Argentina)
Summary: This symposium reunites five speakers that specialize on the pathophysiology of neurodegenerative disorders including Alzheimer’s, Parkinson’s and Prion diseases. The talks will discuss state-of-the-art work based on structural and molecular biology, neurogenetics, cellular, and transgenic mouse models, aimed at elucidating the etiology of these disorders and devising potential therapeutic strategies.
- Presentation 1: Conditional mouse models of TDP-43 proteinopathies - Speaker: Lionel Muller Igaz (Argentina)
- Presentation 2: Protein SUMOylation in Alzheimer’s disease - Speaker: Helena Cimarosti (Brazil)
- Presentation 3: Phenotypic rescue in a mouse model of tauopathy using trans-splicing RNA reprogramming - Speaker: Elena Avale (Argentina)
- Presentation 4: Cellular Prion is a resistance factor for the development of type 2 diabetes - Speaker: Glaucia N. M. Hajj (Brazil)
- Presentation 5: Novel α-Synunclein mediates the pathogenic mutation-dependent mitochondrial dysfunction in Parkinson’s Disease - Speaker: Tomas Falzone (Argentina)

Professor John G. Nicholls celebration symposium. Function, repair and training of the nervous system

Chairs: Elaine Del-Bel (Brazil) and Francisco De Miguel (Mexico)
Summary: Professor John Nicholls will give a lecture about his views on neurosciences and many other issues followed by an informal discussion. This is one of the activities for which John is most remembered by students everywhere in the world. It will give an unique opportunity for many new students and also to his former ones.  The lecture will be held during lunch time; very simple food will be available.
- Presentation 1: Microglial cell dysregulation in brain aging and neurodegeneration - Speaker: Rommy Von Bernhardi (Chile)
- Presentation 2: Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila - Speaker: Liria Masuda-Nakagawa (UK)
- Presentation 3: The alteration of neonatal raphe neurons by prenatal-perinatal nicotine. Meaning for sudden infant death syndrome - Speaker: Jaime Eugenin (Chile)
- Presentation 4: Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury - Speaker: Keneth Muller (USA)
- Presentation 5: The structure and function of 'active zone material' at synapses - Speaker: U. J. McMahan (USA)

Young Investigator Symposia: (on call)